Specialist - Carbohydrate and Glycoscience Process Development
Aurigene Pharmaceutical Services LimitedJob Description
Job Discription : Advanced Carbohydrate & Glycoscience Process Development π Hyderabad / Bengaluru, India About the Role We are looking for an experienced Carbohydrate & Glycoscience Process Development Scientist to lead complex carbohydrate and oligosaccharide projects from early route assessment through process development, scale-up, technology transfer, and manufacturing support. This is a unique opportunity to work at the forefront of carbohydrate chemistry, synthetic glycans, glycoconjugates, and advanced process development, while collaborating with global customers and mentoring high-performing scientific teams. Key Responsibilities Scientific Leadership - Lead carbohydrate and oligosaccharide development programs from proof-of-concept to commercial manufacturing. - Design and optimize scalable processes involving glycosylation, protection/deprotection, selective functionalization, azidation, and oligosaccharide assembly. - Drive troubleshooting, root-cause investigations, and process improvements using analytical and reaction data. Process Development & Scale-Up - Develop robust, safe, and commercially viable manufacturing processes. - Support scale-up activities from laboratory to pilot and manufacturing scale. - Conduct process safety evaluations and support technology transfer activities. Customer Engagement - Act as the scientific lead for customer-facing projects. - Present project progress, technical recommendations, risks, and mitigation plans. - Participate in technical discussions, project reviews, site visits, and proposal presentations. Team & Project Management - Mentor and guide junior scientists. - Review experimental strategies, technical reports, and project documentation. - Coordinate cross-functional activities with Analytical R&D, Manufacturing, Quality, Engineering, Regulatory, Supply Chain, and Project Management teams. Innovation & Capability Building - Explore advanced glycan synthesis approaches, automated glycan assembly, and high-throughput experimentation. - Contribute to capability development in glycan characterization, glycoconjugates, and next-generation carbohydrate technologies. - Conduct literature, patent, and technology assessments to drive innovation. Required Qualifications Education - Ph.D. in Organic Chemistry, Carbohydrate Chemistry, Glycoscience, Medicinal Chemistry, or a related discipline. Experience - Proven industry experience in carbohydrate and oligosaccharide synthesis and process development. - Strong expertise in glycosylation chemistry, stereochemical control, and protecting-group strategies. - Experience supporting technology transfer, scale-up, and manufacturing operations. Technical Skills - Deep understanding of carbohydrate process chemistry and impurity control. - Hands-on experience with HPLC/UPLC, LC-MS, HRMS, NMR, GC, and KF techniques. - Knowledge of crystallization, purification, and isolation of complex and highly polar molecules. - Familiarity with process safety, DoE/QbD principles, and scalable manufacturing processes. Leadership Skills - Strong project management and stakeholder management capabilities. - Excellent scientific writing, presentation, and communication skills. - Ability to mentor teams and deliver projects in a fast-paced environment. Preferred Experience - Glycoconjugate vaccines, synthetic glycans, carbohydrate therapeutics, or carbohydrate-based APIs. - CRO/CDMO process development environment. - Publications, patents, or postdoctoral research in carbohydrate chemistry or glycoscience. - Experience with advanced purification technologies and scalable glycan manufacturing. What Success Looks Like β Successful delivery of carbohydrate programs from concept to technology transfer β Robust, scalable, and commercially viable manufacturing processes β Strong customer partnerships and repeat business opportunities β Development of scientific talent through mentoring and leadership β Advancement of glycoscience capabilities and innovation platforms