Research Fellow (Life Sciences Institute, Neurobiology)

Job Title: Research Fellow (Life Sciences Institute, Neurobiology) University-Level Unit: Life Sciences Institute Faculty/Department-Level Unit: Research & Programmes Employee Category: Research Staff Location_ONB: Kent Ridge Campus Posting Start Date: 04/09/2026 Job Description The Neurobiology Research Programme at the Life Sciences Institute, led by Professor Rickie Patani, invites applications for a highly motivated and accomplished Research Fellow to join a world-leading laboratory investigating the molecular mechanisms of motor neuron disease, with a particular focus on Amyotrophic Lateral Sclerosis (ALS). The Research Fellow will lead a strategically designed research programme examining the intersection between genomic instability and dysregulated RNA metabolism in ALS. A central objective will be to dissect how altered RNA processing — including intron retention — contributes to neurodegenerative vulnerability. Key Responsibilities - Conceive, design, and execute high-impact research initiatives aligned with programme strategy. - Establish, optimise, and oversee complex experimental platforms, ensuring rigorous methodological and analytical standards. - Lead and mentor junior researchers and students, fostering a collaborative and inclusive laboratory culture. - Integrate experimental and computational datasets, including high-throughput sequencing and advanced imaging analyses. - Prepare manuscripts for submission to leading peer-reviewed journals and contribute to competitive grant applications. - Present research findings at national and international scientific meetings. - Contribute to teaching activities within NUS, supporting curriculum development linked to translational neuroscience. - Maintain exemplary standards of data management, compliance, and laboratory governance. Qualifications Applicants should hold a PhD in Neuroscience, Biomedical Sciences, or a closely related discipline, with demonstrated expertise in ALS research or related neurodegenerative disorders. Essential Experience Includes - Human iPSC culture and differentiation into neural subtypes - Advanced molecular biology techniques - High-throughput data analysis (e.g., RNA sequencing, imaging datasets) - Experience with ALS-relevant mouse models Desirable Experience - Human post-mortem tissue analysis - Computational biology and bioinformatics (coding proficiency preferred) - Supervision of postgraduate or early-career researchers Candidates Must Demonstrate - A strong publication record in high-impact peer-reviewed journals - Evidence of scientific independence and international visibility - Excellent organisational, communication, and leadership skills - Commitment to mentoring and fostering an inclusive research environment Req ID: 31861

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